Sickle Cell Disease Insights

RFK Jr. Discusses Sickle Cell Treatment in Charleston

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Latest Research

A recent systematic review by Yassin et al.

(2025)
analyzed three newer medications for sickle cell disease (SCD) – l-glutamine, crizanlizumab, and voxelotor – focusing on their ability to reduce complications like pain crises.

While these drugs represent important advances, the review highlights the need to better understand their real-world effectiveness compared to older treatments like hydroxyurea.

The study emphasizes that while these therapies show promise in managing symptoms, gaps remain in understanding long-term benefits and how they work for different patients.

This research helps doctors and patients weigh treatment options while underscoring the ongoing need for more comprehensive solutions beyond current medications.

Clinical Trials

This is a list of upcoming or ongoing clinical trials that are actively recruiting and have been listed or updated in the last two weeks:
A Study to Investigate the Safety, Tolerability, and Pharmacokinetics of Oral GSK4172239D Compared With Placebo in Sickle Cell Disease Participants Aged 18 to 50 Years
Study Type
Phase I
Location
United States
Age Range
18 - 50 Years
Enrollment
40
Safety, Efficacy, and Pharmacokinetics of CSL889 in Adults and Adolescents With Sickle Cell Disease During Vaso-Occlusive Crisis
Study Type
Phase III
Location
United States
Age Range
12+ Years
Enrollment
260
Comparing the Effectiveness of Matched Related Donor Hematopoietic Stem Cell Transplantation to Disease Modifying Therapy in Pediatric Patients With Sickle Cell Disease
Study Type
Observational
Location
2 countries
Age Range
3 - 20 Years
Enrollment
480
Genotype -Phenotype Correlation of PKLR Variants With Pyruvate Kinase, 2,3-Diphosphglycerate and Adenosine Triphosphate Activities in Red Blood Cells of People With Sickle Cell Disease
Study Type
Observational
Location
Maryland
Age Range
18 - 80 Years
Enrollment
800

Community News

Sickle Cell 101Sickle Cell 101Apr 28, 2025

Living with sickle cell disease in a nutshell

#SickleCell#SickleCell101

SCD Association of America, IncSCD Association of America, IncApr 26, 2025

With great sadness, SCDAA shares the news of the loss of Dr. Gwendolyn Poles-Corker on April 8, 2025. The 71-year-old was a trailblazing physician, educator, advocate and sickle cell warrior. She passed away from complications of her disease, but she never let it hold her back. She overcame the odds and brought healing and care to her patients and community. Dr. Poles-Corker supported SCDAA’s work and served as a member of the SCDAA Advisory Board until her passing. Her guidance and leadership will be deeply missed. Learn more: https://buff.ly/XXd6IzT

Global Alliance of Sickle Cell Disease OrganizationsGlobal Alliance of Sickle Cell Disease OrganizationsApr 25, 2025

Let's talk about Priapism in Sickle Cell Disease!

Male with Sickle cell and their caregivers must be informed of the risk and empowered to seek help without hesitation.

Global Alliance of Sickle Cell Disease Organizations Post

Upcoming Events

JUN
19
Summer Sickletini Happy Hour In Person SCD Association of America, Inc • Hanover, MD
JUL
20
Medically supervised camp for children In Person Sickle Cell Disease Foundation • Ontario, CA